(Reuters) ? The New York Times Co, which is grappling with sinking advertising revenue and a recent change in the top management, said it continued to add subscribers for its digital products in the fourth quarter.
The company started 2012 without a CEO or a digital boss as long-term Chief Executive Janet Robinson stepped down last December, and longtime digital leader Martin Nisenholtz retired.
Publisher Arthur Sulzberger Jr. has taken up the top job in the interim as the company continues its search for a replacement for Robinson.
"As for the CEO search, it is in its early stages, as our board seeks to find the appropriate executive with digital and brand-building experience to help guide this company and its long-term growth strategy," Sulzberger said in a post-earnings analyst call.
The problems plaguing newspaper companies are well known. Readers have ditched print for digital, causing circulation and advertising revenue to plummet.
The company, which rolled out an online pay system last year for digital subscribers, said paid digital subscribers of The Times and the International Herald Tribune rose 20 percent from the third quarter to about 390,000.
The digital subscription strategy helped circulation revenue to grow 5 percent to $241.6 million in the fourth quarter.
"We are confident that our plan to sustain momentum through the rollout of a series of new features, functions and content will enable us to steadily build our digital progress to date," Chief Financial Officer James Follo said on the call.
The Boston Globe, another of the company's newspapers that rolled out online paid content offering last October, has 16,000 subscribers.
AD REVENUE FALLS
Digital advertising revenue fell 5 percent to $95.7 million as higher revenue at the News Media Group were more than offset by declines at the About Group.
About Group revenue fell more than a quarter to $26.1 million as both cost-per-click and display advertising declined.
CFO Follo is now overseeing About.com, which provides short articles, videos and other content that tend to appear high in search queries and sells advertising against those results.
The company expects total advertising revenue trends in the first quarter to be similar to the fourth-quarter levels, and total circulation revenue to increase in the high-single digits.
Total advertising revenue fell 7 percent to $358.5 million.
Fourth-quarter net income fell to $58.9 million, or 39 cents a share, from $67.1 million, or 44 cents a share, a year ago.
Excluding items, it earned 45 cents a share on a continuing basis.
Revenue fell 3 percent to $642.9 million.
Shares of the company, which have gained more than 30 percent in value in the last three months, were flat at $7.64 on Thursday afternoon on the New York Stock Exchange.
(Reporting by Supantha Mukherjee in Bangalore; Editing by Joyjeet Das, Unnikrishnan Nair)
Everybody would like their final days to be free from pain, particularly with those who have terminal sicknesses. They want to be treated with love, dignity and understanding through the final days of their life. They wish to be surrounded by family, friends and their loved ones. To fulfill this, Hospice care can there be to ensure their wishes will become a reality.
Hospice care was established to offer comfort to patients when their sickness are typically no longer treatable. Contrary to popular beliefs, hospice care would not hasten the finish of the life of their patient, but the objective would be to offer relief and dignity to the sufferer and their loved ones. Whenever possible they might want to manage the discomfort of the sufferer and provide ease and momentary comfort. They even offer counseling to the family members both before and after the sufferer?s death. The most important purpose of hospice care is to steer the focus of the sufferer to uplifting the high quality of their life and not with how long their remaining lifespan will likely be.
Hospice care is given every single hour of the day, whether you are in a hospital, at the nursing home, special hospice centers or in the patient?s residence. Hospice is used as soon as all the methods of remedy to illness have already been used up. A large amount of Hospice care in America is in the home of the sufferer, and is provided by family caregivers. However, they are assisted by a hospice nurse or a home health aide.
Furthermore, Hospice does not avoid the truth about ?dying.? Instead, they consider dying as a natural cycle in an individual?s existence that had to be confronted with respect and dignity. There are numerous experts that constitute a Hospice team, such as doctors, nurses, psychologists, clergy and social workers.
Hospice care services are mostly covered by several private insurance providers, as well as both Medicaid and Medicare.
Way back many hundreds of years ago, whenever a traveler was on a pilgrimage they?d frequently visit a hospice home for food, medical treatment, and shelter. As years passed by, these hospices grew to be popular as a place for travelers that were sick and dying. Hospice care services grew to be well-known in America in the late 1970?s.
The services connected with Hospice care features a group of professionals that are performing jointly to give understanding, care, and support for the sufferer and their loved ones. They even help in alleviating patient?s pains. They ensure that patients are comfortable by carefully managing the pain and side effects of medicines.
Next, they offer thorough spiritual care. This may include helping the sufferer accept his or her condition, help with saying goodbye with regards to their family and friends, help with satisfying unfinished businesses, and assistance with specific religious ceremonies. The care provided also extends to the patient?s family.
Hospice services also offer assistance when the sufferer has to be admitted into hospitals. They even provide break time for family caregivers to allow them to get some sleep as well as to run their own personal tasks. Bereavement guidance is also offered pre and post the patient?s death.
Hospice in the Home
Hospice at home permits the sufferer to enjoy their very last moments with comfort and with the company of their family. They provide the best conceivable care for both the patient and the family members. Medicare partners with hospice home care in giving tools required and health insurance coverage for healthcare expenses.
Palliative Hospice
Palliative hospice is a treatment to reduce the individual?s symptoms and pain and also to permit it to be better for them to bear. They give all types of needs into the sufferer?s life, such as spiritual, physical, emotional, and social needs.
Hospice Nursing
These are given by licensed and skilled caregivers. They are extremely compassionate and specially trained to provide care for sufferers who are terminally ill.
You can find the closest hospice agency located in your area by contacting your local hospitals and The National Association for Home Care and Hospice.
When a senior is in their final days, Hospice Care can provide comfort to the terminally ill along with their family around the clock, whether at home or within a healthcare facility. Visit Care For Seniors to find out how.
Tagged with: Care For Senior ? Care for Seniors ? Health ? Hospice Care ? senior care
Filed under:
Health
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Overall Transparency: You should provide a 100% having access to your franchisor towards the financial statements to your business. You are completely accountable together with answerable for each business move to these individuals. If you have to create a business decision, you have to first search for the authorization of the franchisor before you decide to act upon it.
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FGS employs some sort of team for professionals who currently have diversified skills, enabling these to consult with their clients on franchise enlargement, marketing practices and vips and other earnings generation tactics. Over the decades FGS has developed a lot of the fastest thriving and highly regarded franchises in the regional.
To be considered for the McDonald?s franchise drug abuse must be capable of handling rapid improvement as well as the ability to thoroughly recognize all aspects for finances during the business realm.
Picking a franchise opportunity isn?t easy, but try not to be tempted by taking a faster way with ?get vibrant quick? adverts ? specially those that show on the internet. One other thing be wary for is franchisors which are pushy ? conceivably they are providing you a limited period deal and therefore are trying to rush you to a decision. If you can?t take your time, you may well get entering into some sort of business agreement that you?ll only regret further down the line.
The common studies on being successful ratios tend to be challenged by means of some who indicate interruptions in the confirming requirements of methods franchise companies ought to provide the material. You have to remember, any franchisers want the data to look good. Think about making sure that a person address consume topics so that you are making a knowledgeable decision, not only for an emotional one. Obtaining many franchise information needed to be well informed can be your responsibility.
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The next important aspect is hiring. This is the most difficult job because the lifetime of business depends on your service crew. These are your the front liners so you have to get the best one of the better. Make sure that before you decide to hire, that you are set with your policies together with legal requirements. In the training, always be able to request information from them any operations protection plan of the business consuming become any the Holy book for everyone involved in the business.
Copy resourced by http://www.laundromatfranchise.org and the thoughts of Kevin lyod
How antipsychotic medications cause metabolic side effects such as obesity and diabetesPublic release date: 1-Feb-2012 [ | E-mail | Share ]
Contact: Heather Buschman, Ph.D. hbuschman@sanfordburnham.org 858-795-5343 Sanford-Burnham Medical Research Institute
Sanford-Burnham study suggests that many antipsychotics affect metabolism because they activate the TGFbeta pathway -- a finding that could lead to safer therapeutics for bipolar disorder and schizophrenia patients
LA JOLLA, Calif. -- In 2008, roughly 14.3 million Americans were taking antipsychoticstypically prescribed for bipolar disorder, schizophrenia, or a number of other behavioral disordersmaking them among the most prescribed drugs in the U.S. Almost all of these medications are known to cause the metabolic side effects of obesity and diabetes, leaving patients with a difficult choice between improving their mental health and damaging their physical health. In a paper published January 31 in the journal Molecular Psychiatry, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) reveal how antipsychotic drugs interfere with normal metabolism by activating a protein called SMAD3, an important part of the transforming growth factor beta (TGFbeta) pathway.
The TGFbeta pathway is a cellular mechanism that regulates many biological processes, including cell growth, inflammation, and insulin signaling. In this study, all antipsychotics that cause metabolic side effects activated SMAD3, while antipsychotics free from these side effects did not. What's more, SMAD3 activation by antipsychotics was completely independent from their neurological effects, raising the possibility that antipsychotics could be designed that retain beneficial therapeutic effects in the brain, but lack the negative metabolic side effects.
"We now believe that many antipsychotics cause obesity and diabetes because they trigger the TGFbeta pathway. Of all the drugs we tested, the only two that didn't activate the pathway were the ones that are known not to cause metabolic side effects," said Fred Levine, M.D., Ph.D., director of the Sanford Children's Health Research Center at Sanford-Burnham and senior author of the study.
In a previous study aimed at developing new insights into diabetes, Dr. Levine and his team used Sanford-Burnham's high-throughput screening capabilities to search a collection of known drugs for those that alter the body's ability to generate insulin, the pancreatic hormone that helps regulate glucose. That's when they first noticed that many antipsychotics alter the activity of the insulin gene. In this current study, the researchers set out to connect the dots between antipsychotics and insulin. In doing so, experiments in laboratory cell-lines showed that antipsychotics known to cause metabolic side effects also activated the TGFbeta pathwaya mechanism that controls many cellular functions, including the production of insulinwhile the drugs without these side effects did not.
Wondering whether their initial laboratory observations were relevant to the human experience, the researchers reanalyzed previously published gene expression patterns in brain tissue from schizophrenic patients treated with antipsychotics. What they found supported their earlier findingsTGFbeta signaling was activated only in those patients receiving antipsychotic treatment. Looking further, they found that the extent to which each antipsychotic drug activated the TGFbeta pathway in human brains correlated very closely with the extent to which those same drugs activated SMAD3 and affected the insulin promoter in their cell culture experiments.
The TGFbeta pathway also plays an important role in metabolic disease in people who don't take antipsychotic medications. "It's known that people who have elevated TGFbeta levels are more prone to diabetes. So having a dysregulated TGFbeta pathwaywhether caused by antipsychotics or through some other mechanismis clearly a very bad thing," said Dr. Levine. "The fact that antipsychotics activate this pathway should be a big concern to pharmaceutical companies. We hope this new information will lead to the development of improved drugs."
###
This study was funded by a gift from Mr. T. Denny Sanford to the Sanford Children's Health Research Center at Sanford-Burnham. Co-authors include Thomas Cohen, Sanford-Burnham and University of California, San Diego; S. Sundaresh, NextBio; and Fred Levine, Sanford-Burnham.
About Sanford-Burnham Medical Research Institute
Sanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. The Institute consistently ranks among the top five organizations worldwide for its scientific impact in the fields of biology and biochemistry (defined by citations per publication) and currently ranks third in the nation in NIH funding among all laboratory-based research institutes. Sanford-Burnham is a highly innovative organization, currently ranking second nationally among all organizations in capital efficiency of generating patents, defined by the number of patents issued per grant dollars awarded, according to government statistics.
Sanford-Burnham utilizes a unique, collaborative approach to medical research and has established major research programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is especially known for its world-class capabilities in stem cell research and drug discovery technologies. Sanford-Burnham is a U.S.-based, non-profit public benefit corporation, with operations in San Diego (La Jolla), Santa Barbara, and Orlando (Lake Nona). For more information, please visit our website (http://www.sanfordburnham.org) or blog (http://beaker.sanfordburnham.org). You can also receive updates by following us on Facebook and Twitter.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
How antipsychotic medications cause metabolic side effects such as obesity and diabetesPublic release date: 1-Feb-2012 [ | E-mail | Share ]
Contact: Heather Buschman, Ph.D. hbuschman@sanfordburnham.org 858-795-5343 Sanford-Burnham Medical Research Institute
Sanford-Burnham study suggests that many antipsychotics affect metabolism because they activate the TGFbeta pathway -- a finding that could lead to safer therapeutics for bipolar disorder and schizophrenia patients
LA JOLLA, Calif. -- In 2008, roughly 14.3 million Americans were taking antipsychoticstypically prescribed for bipolar disorder, schizophrenia, or a number of other behavioral disordersmaking them among the most prescribed drugs in the U.S. Almost all of these medications are known to cause the metabolic side effects of obesity and diabetes, leaving patients with a difficult choice between improving their mental health and damaging their physical health. In a paper published January 31 in the journal Molecular Psychiatry, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) reveal how antipsychotic drugs interfere with normal metabolism by activating a protein called SMAD3, an important part of the transforming growth factor beta (TGFbeta) pathway.
The TGFbeta pathway is a cellular mechanism that regulates many biological processes, including cell growth, inflammation, and insulin signaling. In this study, all antipsychotics that cause metabolic side effects activated SMAD3, while antipsychotics free from these side effects did not. What's more, SMAD3 activation by antipsychotics was completely independent from their neurological effects, raising the possibility that antipsychotics could be designed that retain beneficial therapeutic effects in the brain, but lack the negative metabolic side effects.
"We now believe that many antipsychotics cause obesity and diabetes because they trigger the TGFbeta pathway. Of all the drugs we tested, the only two that didn't activate the pathway were the ones that are known not to cause metabolic side effects," said Fred Levine, M.D., Ph.D., director of the Sanford Children's Health Research Center at Sanford-Burnham and senior author of the study.
In a previous study aimed at developing new insights into diabetes, Dr. Levine and his team used Sanford-Burnham's high-throughput screening capabilities to search a collection of known drugs for those that alter the body's ability to generate insulin, the pancreatic hormone that helps regulate glucose. That's when they first noticed that many antipsychotics alter the activity of the insulin gene. In this current study, the researchers set out to connect the dots between antipsychotics and insulin. In doing so, experiments in laboratory cell-lines showed that antipsychotics known to cause metabolic side effects also activated the TGFbeta pathwaya mechanism that controls many cellular functions, including the production of insulinwhile the drugs without these side effects did not.
Wondering whether their initial laboratory observations were relevant to the human experience, the researchers reanalyzed previously published gene expression patterns in brain tissue from schizophrenic patients treated with antipsychotics. What they found supported their earlier findingsTGFbeta signaling was activated only in those patients receiving antipsychotic treatment. Looking further, they found that the extent to which each antipsychotic drug activated the TGFbeta pathway in human brains correlated very closely with the extent to which those same drugs activated SMAD3 and affected the insulin promoter in their cell culture experiments.
The TGFbeta pathway also plays an important role in metabolic disease in people who don't take antipsychotic medications. "It's known that people who have elevated TGFbeta levels are more prone to diabetes. So having a dysregulated TGFbeta pathwaywhether caused by antipsychotics or through some other mechanismis clearly a very bad thing," said Dr. Levine. "The fact that antipsychotics activate this pathway should be a big concern to pharmaceutical companies. We hope this new information will lead to the development of improved drugs."
###
This study was funded by a gift from Mr. T. Denny Sanford to the Sanford Children's Health Research Center at Sanford-Burnham. Co-authors include Thomas Cohen, Sanford-Burnham and University of California, San Diego; S. Sundaresh, NextBio; and Fred Levine, Sanford-Burnham.
About Sanford-Burnham Medical Research Institute
Sanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. The Institute consistently ranks among the top five organizations worldwide for its scientific impact in the fields of biology and biochemistry (defined by citations per publication) and currently ranks third in the nation in NIH funding among all laboratory-based research institutes. Sanford-Burnham is a highly innovative organization, currently ranking second nationally among all organizations in capital efficiency of generating patents, defined by the number of patents issued per grant dollars awarded, according to government statistics.
Sanford-Burnham utilizes a unique, collaborative approach to medical research and has established major research programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is especially known for its world-class capabilities in stem cell research and drug discovery technologies. Sanford-Burnham is a U.S.-based, non-profit public benefit corporation, with operations in San Diego (La Jolla), Santa Barbara, and Orlando (Lake Nona). For more information, please visit our website (http://www.sanfordburnham.org) or blog (http://beaker.sanfordburnham.org). You can also receive updates by following us on Facebook and Twitter.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
>>>a verdict has been reached in a murder case that's gotten a lot of attention because it involved so-called
honor killings
of family members by family members. in this case an afghan family living in
canada
. it is a
culture clash
getting a lot of attention to our north. nbc's kevin tibbles has the story.
>> reporter: three teenage sisters murdered because of how they wanted 2 live their lives. dress like westerners, use the internet, meet boys. also killed, their father's first wife. by a strict religious family that felt it had been disgraced.
>>four strong, vivacious and freedom-loving women were murdered by their family.
>> reporter: convicted of the crime, the girls' father, mother and brother, immigrants from afghanistan. in
2009
, the women were drowned and their bodies placed in a car that was then pushed onto a canal to look like an accident. they may call it
honor killing
, but delivering the
guilty verdict
, the canadian judge called it a sick notion of honor that has absolutely no place in any civilized society. 59-year-old mohammed shafia came to
canada
in
2007
. the court was told how he ruled his home with a rod of iron. and that eldest daughter was even forbidden to attend school because she had a boyfriend. the
young woman
had texted the boy saying, "be aware of my bro." it is impossible to know how many
honor killings
take place in
north america
, experts say, because they are often mistaken for domestic violence or disguised as accidents.
>>they are associated with patriarch cultures, where then see themselves as the owners of women.
>> reporter: the took a jury 15 hours to convict all three of first degree murder, which in
canada
carries an automatic sentence of
life in prison
. ken tibbles, nbc news,
canada
.
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